Use of 16S rRNA Analysis To Investigate Phylogeny of Methylotrophic Bacteria Bratina, Bonnie Jo and Brusseau, Gregory A. and Hanson, Richard S.,, 42, 645-648 (1992), doi = https://doi.org/10.1099/00207713-42-4-645, publicationName = Microbiology Society, issn = 1466-5026, abstract= Small-subunit rRNAs from 24 gram-negative methylotrophic bacteria have been sequenced. A phylogenetic tree was constructed on the basis of sequence similarities by using a weighted least-mean-square difference method. The methylotrophs were separated into coherent clusters in which bacteria in each group shared physiological characteristics., language=, type=