Organization and Phylogenetic Interrelationships of Genes Encoding Components of the Botulinum Toxin Complex in Proteolytic Clostridium botulinum Types A, B, and F: Evidence of Chimeric Sequences in the Gene Encoding the Nontoxic Nonhemagglutinin Component

References

1. Binz T., Kurazono H., Wille M., Frevert J., Wernars K., Niemann H. 1990; The complete sequence of botulinum neurotoxin type A and comparison with other clostridial neurotoxins. J. Biol. Chem 265:9153–9158
   [Google Scholar]
2. Campbell K. D., Collins M. D., East A. K. 1993; Gene probes for identification of the botulinal neurotoxin gene and specific identification of neurotoxin types B, E, and F. J. Clin. Microbiol 31:2255–2262
   [Google Scholar]
3. Campbell K. D., Collins M. D., East A. K. 1993; Nucleotide sequence of the gene coding for Clostridium botulinum (Clostridium argentinense) type G neurotoxin: genealogical comparison with other clostridial neurotoxins. Biochem. Biophys. Acta 1216:487–491
   [Google Scholar]
4. Cordoba J. J., Collins M. D., East A. K. 1995; Studies on the genes encoding botulinum neurotoxin type A of Clostridium botulinum from a variety of sources. Syst. Appl. Microbiol 18:13–22
   [Google Scholar]
5. Devereux J., Haeberli P., Smithies D. 1984; A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res 12:387–395
   [Google Scholar]
6. East A K., Collins M. D. 1994; Conserved structure of genes encoding components of botulinum neurotoxin complex M and the sequence of the gene coding for the nontoxic component in non-proteolytic Clostridium botulinum type F. Curr. Microbiol 29:69–77
   [Google Scholar]
7. East A K., Collins M. D. Unpublished data
8. East A. K., Stacey J. M., Collins M. D. 1994; Cloning and sequencing of a hemagglutinin component of the botulinum neurotoxin complex encoded by Clostridium botulinum types A and B. Syst. Appl. Microbiol 17:306–312
   [Google Scholar]
9. East A. K., Stacey J. M., Hielm S., Collins M. D. Unpublished data
10. Elmore M. J., Hutson R. A., Collins M. D., Bodsworth N. J., Whelan S. M., Minton N. P. 1995; Nucleotide sequence of the gene coding for proteolytic (group I) Clostridium botulinum type F neurotoxin: genealogical comparison with other clostridial neurotoxins. Syst. Appl. Microbiol 18:23–31
    [Google Scholar]
11. Felenstein J. 1989; PHYLIP-phylogeny inference package (version 3.2). Cladistics 5:164–166
    [Google Scholar]
12. Franciosa G., Ferreira J. L., Hatheway C. L. 1994; Detection of type A, B and E botulism neurotoxin genes in Clostridium botulinum and other Clostridium species by PCR: evidence of unexpressed type B toxin genes in type A toxigenic organisms. J. Clin. Microbiol 32:1911–1917
    [Google Scholar]
13. Fujii N., Kimura K., Yokosawa N., Oguma K., Yashiki T., Takeshi K., Ohyama T., Isogai E., Isogai H. 1993; Similarity in nucleotide sequence of the gene encoding nontoxic component of botulinum toxin produced by toxigenic Clostridium butyricum strain BL6340 and Clostridium botulinum type E strain Mashike. Microbiol. Immunol 37:395–398
    [Google Scholar]
14. Fujii N., Kimura K., Yokosawa N., Yashiki T., Takeshi K., Tsuzuki K., Oguma K. 1993; The complete nucleotide sequence of the gene encoding the nontoxic component of Clostridium botulinum type E progenitor toxin. J. Gen. Microbiol 139:79–86
    [Google Scholar]
15. Fujinaga Y., Inoue K., Shimazaki S., Tomochika K., Tsuzuki K., Fujii N., Watanabe T., Ohyama T., Takeshi K., Inoue K., Oguma K. 1994; Molecular construction of Clostridium botulinum type C progenitor toxin and its gene organization. Biochem. Biophys. Res. Commun 205:1291–1298
    [Google Scholar]
16. Fujita R., Fujinaga Y., Inoue K., Nakajima H., Kumon H., Oguma K. 1995; Molecular characterization of two forms of nontoxic-nonhemagglutinin components of Clostridium botulinum type A progenitor toxins. FEBS Lett 376:41–44
    [Google Scholar]
17. Garnier T., Cole S. T. 1988; Studies of UV-inducible promoters from Clostridium perfringens in vivo and in vitro. Mol. Microbiol 2:607–614
    [Google Scholar]
18. Hatheway C. L. 1992 Clostridium botulinum and other clostridia that produce botulinum neurotoxin. 3–20 Hauschild A. W., Dodds K. L.ed Clostridium botulinum– ecology and control in foods Marcel Dekker; New York:
    [Google Scholar]
19. Hauser D., Eklund M. W., Boquet P., Popoff M. R. 1994; Organization of the botulinum neurotoxin Cl gene and its associated non-toxic protein genes in Clostridium botulinum C468. Mol. Gen. Genet 243:631–640
    [Google Scholar]
20. Hutson R. A., Collins M. D., East A. K., Thompson D. E. 1994; Nucleotide sequence of the gene coding for non-proteolytic Clostridium botulinum type B neurotoxin: comparison with other clostridial neurotoxins. Curr. Microbiol 28:101–110
    [Google Scholar]
21. Hutson R. A., Collins M. D., Zhou Y., Jiang J., Sugiyama H., Johnson E. A., Hatheway C. L. 1996; Genetic characterization of Clostridium botulinum type A containing silent type B neurotoxin gene sequences. J. Biol. Chem 271:10786–10792
    [Google Scholar]
22. Hutson R. A., Thompson D. E., Lawson P. A., Schocken-Itturino R. P., Bottger E. C., Collins M. D. 1993; Genetic interrelationships of proteolytic Clostridium botulinum type A, B, and F and other members of the Clostridium botulinum complex as revealed by 16S rRNA gene sequences. Antonie van Leeuwenhoek 64:278–283
    [Google Scholar]
23. Lawson P. A., Gharbia S. E., Shah H. N., Clark D. J. 1989; Recognition of Fusobacterium nucleatum subgroups Fn-1, Fn-2 and Fn-3 by ribosomal RNA gene restriction patterns. FEMS Microbiol. Lett 65:41–46
    [Google Scholar]
24. Lonetto M., Gribskov M., Gross C. A. 1992; The σ⁷⁰ family: sequence conservation and evolutionary relationships. J. Bacteriol 174:3843–3849
    [Google Scholar]
25. Nukina M., Mochida Y., Sakaguchi S., Sakaguchi G. 1991; Difficulties of molecular dissociation of Clostridium botulinum type G progenitor toxin. FEMS Microbiol. Lett 79:165–170
    [Google Scholar]
26. Ohishi I., Sakaguchi G. 1975; Molecular construction of Clostridium botulinum type F progenitor toxin. Appl. Microbiol 29:444–447
    [Google Scholar]
27. Saitou N., Nei M. 1987; The neighbor-joining method: a new method for constructing phylogenic trees. Mol. Biol. Evol 4:406–425
    [Google Scholar]
28. Somers E., DasGupta B. R. 1991; Clostridium botulinum types A, B, Cl, and E produce proteins with or without hemagglutinating activity: do they share common amino acids sequences and genes. J. Prot. Chern 10:415–425
    [Google Scholar]
29. Sugii S., Ohisi I., Sakaguchi G. 1977; Correlation between oral toxicity and in vitro stability of Clostridium botulinum type A and B toxins of different molecular sizes. Infect. Immun 16:910–914
    [Google Scholar]
30. Tabita K., Sakaguchi S., Sakaguchi G. 1991; Distinction between Clostridium botulinum type A strains associated with food-bome botulism and those with infant botulism in Japan in intraintestinal toxin production in infant mice and some other properties. FEMS Microbiol. Lett 79:251–256
    [Google Scholar]
31. Thompson D. E., Brehm J. K., Oultram J. D., Swinfield T. J., Shone C. C., Atkinson T., Melling J., Minton N. P. 1990; The complete amino acid sequence of the Clostridium botulinum type A neurotoxin deduced by nucleotide sequence analysis of the encoding gene. Eur. J. Biochem 189:73–81
    [Google Scholar]
32. Tsuzuki K., Kimura K., Fuji N., Yokosawa N., Indoh T., Murakami T., Oguma K. 1990; Cloning and complete nucleotide sequence of the gene for the main component of hemagglutinin produced by Clostridium botulinum type C. Infect. Immun 58:3173–3177
    [Google Scholar]
33. Tsuzuki K., Kimura K., Fuji N., Yokosawa N., Oguma K. 1992; The complete nucleotide sequence of the gene coding for the nontoxic-nonhem-agglutinin component of Clostridium botulinum type C progenitor toxin. Biochem. Biophys. Res. Commun 183:1273–1279
    [Google Scholar]
34. Whelan S. M., Elmore M. J., Bodsworth N. J., Brehm J. K., Atkinson T., Minton N. P. 1992; Molecular cloning of the Clostridium botulinum structural gene encoding the type B neurotoxin and determination of its entire nucleotide sequence. Appl. Environ. Microbiol 58:2345–2354
    [Google Scholar]
35. Willems A., East A. K., Lawson P. A., Collins M. D. 1993; Sequence of the gene coding for the neurotoxin of Clostridium botulinum type A associated with infant botulism: comparison with other clostridial neurotoxins. Res. Microbiol 144:547–556
    [Google Scholar]