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INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY logo

Volume 66, Issue 7

Recombination and phenotype evolution dynamics of in colonized hosts Free

Abstract

The ample genetic diversity and variability of , and therefore its phenotypic evolution, relate not only to frequent mutation and selection but also to intra-specific recombination. Webb and Blaser applied a mathematical model to distinguish the role of selection and mutation for Lewis antigen phenotype evolution during long-term gastric colonization in infected animal hosts (mice and gerbils). To investigate the role of recombination in Lewis antigen phenotype evolution, we have developed a prior population dynamic by adding recombination term to the model. We simulate and interpret the new model simulation's results with a comparative analysis of biological aspects. The main conclusions are as follows: (i) the models and consequently the hosts with higher recombination rate require a longer time for stabilization; and (ii) recombination and mutation have opposite effects on the size of populations with phenotypes in the range of the most-fit ones (i.e. those that have a selective advantage) due to natural selection, although both can increase phenotypic diversity.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): evolution , Helicobacter pylori , Lewis antigen , mutation , recombination , selection and stabilization
© 2016 IUMS
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2016-07-01
2024-04-20
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Recombination and phenotype evolution dynamics of Helicobacter pylori in colonized hosts
Int J Syst Evol Microbiol 66, 2471 (2016); https://doi.org/10.1099/ijsem.0.001072
/content/journal/ijsem/10.1099/ijsem.0.001072
/content/journal/ijsem/10.1099/ijsem.0.001072
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