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Volume 168, Issue 4

Microcins reveal natural mechanisms of bacterial manipulation to inform therapeutic development Open Access

This article is part of the Bacterial Cell Envelopes collection.

Abstract

Microcins are an understudied and poorly characterized class of antimicrobial peptides. Despite the existence of only 15 examples, all identified from the , microcins display diversity in sequence, structure, target cell uptake, cytotoxic mechanism of action and target specificity. Collectively, these features describe some of the unique means nature has contrived for molecules to cross the ‘impermeable’ barrier of the Gram-negative bacterial outer membrane and inflict cytotoxic effects. Microcins appear to be widely dispersed among different species and in different environments, where they function in regulating microbial communities in diverse ways, including through competition. Growing evidence suggests that microcins may be adapted for therapeutic uses such as antimicrobial drugs, microbiome modulators or facilitators of peptide uptake into cells. Advancing our biological, ecological and biochemical understanding of the roles of microcins in bacterial interactions, and learning how to regulate and modify microcin activity, is essential to enable such therapeutic applications.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): antimicrobial , bacteriocin , Gram-negative , membrane , microcin and therapeutic
Funding
This study was supported by the:
  • Tito's Handmade Vodka
    • Principle Award Recipient: BryanWilliam Davies
  • Defense Advanced Research Projects Agency (Award HR0011-19-2-0011)
    • Principle Award Recipient: William DaviesBryan
  • Defense Threat Reduction Agency (Award HDTRA1-17-C0008)
    • Principle Award Recipient: BryanWilliam Davies
  • National Institutes of Health (Award R01 AI125337, R01 AI148419, R21 AI159203)
    • Principle Award Recipient: BryanWilliam Davies
© 2022 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
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2022-04-19
2024-05-08
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/mic.0.001175
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Microcins reveal natural mechanisms of bacterial manipulation to inform therapeutic development
Microbiology 168, 001175 (2022); https://doi.org/10.1099/mic.0.001175
/content/journal/micro/10.1099/mic.0.001175
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