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Volume 169, Issue 3

Membrane lipids from gut microbiome-associated bacteria as structural and signalling molecules Open Access

This article is part of the Bacterial Cell Envelopes collection.

Abstract

Bacteria produce an array of diverse, dynamic and often complex lipid structures, some of which function beyond their typical role in membrane structure. The model organism, , has three major membrane lipids, which are glycerophosphoglycerol (phosphatidylglycerol), glycerophosphoethanolamine (phosphatidylethanolamine) and cardiolipin. However, it is now appreciated that some bacteria have the capacity to synthesize a range of lipids, including glycerophosphocholines, glycerophosphoinositols, ‘phosphorous-free’ -acyl amines, sphingolipids and plasmalogens. In recent years, some of these bacterial lipids have emerged as influential contributors to the microbe–host molecular dialogue. This review outlines our current knowledge of bacterial lipid diversity, with a focus on the membrane lipids of microbiome-associated bacteria that have documented roles as signalling molecules.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Bacteroidota , glycine lipids , inter-kingdom signalling , plasmalogens and sphingolipids
Funding
This study was supported by the:
  • EU JPI CABALA (Award 3358)
    • Principle Award Recipient: SusanA. Joyce
  • Science Foundation Ireland (Award SFI/12/RC/2273)
    • Principle Award Recipient: SusanA. Joyce
  • APC Microbiome Institute (Award APEX 754535)
    • Principle Award Recipient: EileenRyan
  • EU-H2020-MSCA (Award 887019)
    • Principle Award Recipient: EileenRyan
  • Irish Government Department of Agriculture, Food and the Marine (Award DAFM 17-RD-US-ROI)
    • Principle Award Recipient: SusanA. Joyce
© 2023 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2023-03-23
2024-05-08
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Membrane lipids from gut microbiome-associated bacteria as structural and signalling molecules
Microbiology 169, 001315 (2023); https://doi.org/10.1099/mic.0.001315
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