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Volume 169, Issue 8

Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level Open Access

Abstract

Bacteria live in complex polymicrobial communities and are constantly competing for resources. The type VI secretion system (T6SS) is a widespread antagonistic mechanism used by Gram-negative bacteria to gain an advantage over competitors. T6SSs translocate toxic effector proteins inside target prokaryotic cells in a contact-dependent manner. In addition, some T6SS effectors can be secreted extracellularly and contribute to the scavenging scarce metal ions. Bacteria deploy their T6SSs in different situations, categorizing these systems into offensive, defensive and exploitative. The great variety of bacterial species and environments occupied by such species reflect the complexity of regulatory signals and networks that control the expression and activation of the T6SSs. Such regulation is tightly controlled at the transcriptional, posttranscriptional and posttranslational level by abiotic (e.g. pH, iron) or biotic (e.g. quorum-sensing) cues. In this review, we provide an update on the current knowledge about the regulatory networks that modulate the expression and activity of T6SSs across several species, focusing on systems used for interbacterial competition.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): bacterial antagonism , gene regulation , posttranscriptional regulation , posttranslational regulation , T6SS and transcription factors
Funding
This study was supported by the:
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (Award 2017/02178-2)
    • Principle Award Recipient: EthelBayer-Santos
© 2023 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
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2023-08-08
2024-05-08
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/mic.0.001376
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Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level
Microbiology 169, 001376 (2023); https://doi.org/10.1099/mic.0.001376
/content/journal/micro/10.1099/mic.0.001376
/content/journal/micro/10.1099/mic.0.001376
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