@article{mbs:/content/journal/ijsem/10.1099/ijsem.0.001072, author = "Shafiee, Ahmad and Amini, Massoud and Emamirad, Hassan and Abadi, Amin Talebi Bezmin", title = "Recombination and phenotype evolution dynamics of Helicobacter pylori in colonized hosts", journal= "International Journal of Systematic and Evolutionary Microbiology", year = "2016", volume = "66", number = "7", pages = "2471-2477", doi = "https://doi.org/10.1099/ijsem.0.001072", url = "https://www.microbiologyresearch.org/content/journal/ijsem/10.1099/ijsem.0.001072", publisher = "Microbiology Society", issn = "1466-5034", type = "Journal Article", keywords = "evolution", keywords = "Lewis antigen", keywords = "mutation", keywords = "Helicobacter pylori", keywords = "stabilization", keywords = "selection", keywords = "recombination", abstract = "The ample genetic diversity and variability of Helicobater pylori, and therefore its phenotypic evolution, relate not only to frequent mutation and selection but also to intra-specific recombination. Webb and Blaser applied a mathematical model to distinguish the role of selection and mutation for Lewis antigen phenotype evolution during long-term gastric colonization in infected animal hosts (mice and gerbils). To investigate the role of recombination in Lewis antigen phenotype evolution, we have developed a prior population dynamic by adding recombination term to the model. We simulate and interpret the new model simulation's results with a comparative analysis of biological aspects. The main conclusions are as follows: (i) the models and consequently the hosts with higher recombination rate require a longer time for stabilization; and (ii) recombination and mutation have opposite effects on the size of H. pylori populations with phenotypes in the range of the most-fit ones (i.e. those that have a selective advantage) due to natural selection, although both can increase phenotypic diversity.", }