Identification of a novel NLS of herpes simplex virus type 1 (HSV-1) VP19C and its nuclear localization is required for efficient production of HSV-1
Li, You and Zhao, Lei and Wang, Shuai and Xing, Junji and Zheng, Chunfu,, 93, 1869-1875 (2012),
doi = https://doi.org/10.1099/vir.0.042697-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= Herpes simplex virus type 1 (HSV-1) triplex is a complex of three protein subunits, consisting of two copies of VP23 and one copy of VP19C. Here, we identified a non-classical NLS of VP19C between aa 50 and 61, and the nuclear import of VP19C was mediated by RanGTP and importin β1-, but not importin α5-, dependent pathway. Additionally, recombinant virus harbouring this NLS mutation (NLSm) replicates less efficiently as wild-type. These data strongly suggested that the nuclear import of VP19C is required for efficient HSV-1 production.,
language=,
type=