Identification of an antigenic domain in the N-terminal region of avian hepatitis E virus (HEV) capsid protein that is not common to swine and human HEVs Wang, Lizhen and Sun, Yani and Du, Taofeng and Wang, Chengbao and Xiao, Shuqi and Mu, Yang and Zhang, Gaiping and Liu, Lihong and Widén, Frederik and Hsu, Walter H. and Zhao, Qin and Zhou, En-Min,, 95, 2710-2715 (2014), doi = https://doi.org/10.1099/vir.0.069021-0, publicationName = Microbiology Society, issn = 0022-1317, abstract= The antigenic domains located in the C-terminal 268 amino acid residues of avian hepatitis E virus (HEV) capsid protein have been characterized. This region shares common epitopes with swine and human HEVs. However, epitopes in the N-terminal 338 amino acid residues have never been reported. In this study, an antigenic domain located between amino acids 23 and 85 was identified by indirect ELISA using the truncated recombinant capsid proteins as coating antigens and anti-avian HEV chicken sera as primary antibodies. In addition, this domain did not react with anti-swine and human HEV sera. These results indicated that the N-terminal 338 amino acid residues of avian HEV capsid protein do not share common epitopes with swine and human HEVs. This finding is important for our understanding of the antigenicity of the avian HEV capsid protein. Furthermore, it has important implications in the selection of viral antigens for serological diagnosis., language=, type=