Transcriptional downregulation of DC-SIGN in human herpesvirus 6-infected dendritic cells
Niiya, Hironari and Azuma, Taichi and Jin, Lei and Uchida, Naoyuki and Inoue, Atsushi and Hasegawa, Hitoshi and Fujita, Shigeru and Tohyama, Mikiko and Hashimoto, Koji and Yasukawa, Masaki,, 85, 2639-2642 (2004),
doi = https://doi.org/10.1099/vir.0.80095-0,
publicationName = Microbiology Society,
issn = 0022-1317,
abstract= DC-SIGN expressed on dendritic cells (DCs) efficiently binds and transmits various pathogens, including human immunodeficiency virus, to lymphoid tissues and permissive cells. Consequently, alteration of DC-SIGN expression may affect susceptibility and resistance to pathogens. The present study shows that infection with human herpesvirus 6 (HHV-6) induces downregulation of DC-SIGN expression on immature DCs. Expression levels of DC-SIGN mRNA and intracellular protein appeared to decrease following infection with HHV-6, indicating that downregulation of surface DC-SIGN occurs at the transcriptional level. Downregulation of DC-SIGN was not induced by inoculation of UV-inactivated HHV-6 or culture supernatant of HHV-6-infected DCs, indicating that replication of HHV-6 in DCs is required for downregulation of DC-SIGN. The present study demonstrates for the first time that expression of DC-SIGN is altered at the transcriptional level by virus infection.,
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