RT Journal Article SR Electronic(1) A1 Xu, Dan A1 Saeed, Amir A1 Wang, Yili A1 Seidel, Véronique A1 Sandström, Gunnar A1 Yu, JunYR 2011 T1 Natural products modulate Shigella–host-cell interaction JF Journal of Medical Microbiology, VO 60 IS 11 SP 1626 OP 1632 DO https://doi.org/10.1099/jmm.0.030254-0 PB Microbiology Society, SN 1473-5644, AB This study focused on identifying possible new options derived from natural sources for the treatment of bacterial infections. Several natural products were investigated for their potential in modulating Shigella–host-cell interactions. The proliferation of Shigella sonnei was effectively inhibited inside HEp-2 cells in the presence of 4-methoxycinnamic acid and propolin D. Propolin D also significantly reduced the apoptosis of infected macrophage-like U937 cells and moderately reduced the secretion of interleukin (IL)-1β and IL-18, which probably resulted from the inhibition of invasion plasmid antigen B secretion by this compound. Further characterization showed that propolin D did not prevent escape of Shigella from phagocytic vacuoles, as evidenced by actin-based motility and by the fact that addition of chloroquine did not further reduce the number of intracellular c.f.u. The role of propolin D in modulating autophagy could not be established under the experimental conditions used. As these compounds had no direct anti-Shigella activity in vitro, it was concluded that these compounds modulated Shigella–host-cell interactions by targeting yet-to-be defined mechanisms that provide benefits to host cells., UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.030254-0