Human genome-microbiome interaction: metagenomics frontiers for the aetiopathology of autoimmune diseases Gundogdu, Aycan and Nalbantoglu, Ufuk,, 3, e000112 (2017), doi = https://doi.org/10.1099/mgen.0.000112, publicationName = Microbiology Society, issn = , abstract= A short while ago, the human genome and microbiome were analysed simultaneously for the first time as a multi-omic approach. The analyses of heterogeneous population cohorts showed that microbiome components were associated with human genome variations. In-depth analysis of these results reveals that the majority of those relationships are between immune pathways and autoimmune disease-associated microbiome components. Thus, it can be hypothesized that autoimmunity may be associated with homeostatic disequilibrium of the human-microbiome interactome. Further analysis of human genome–human microbiome relationships in disease contexts with tailored systems biology approaches may yield insights into disease pathogenesis and prognosis., language=, type=