Microbe Profile: Wolbachia: a sex selector, a viral protector and a target to treat filarial nematodes: This article is part of the Microbe Profiles collection.

Mark J. Taylor; Seth R. Bordenstein; Barton Slatko

doi:10.1099/mic.0.000724

Volume 164, Issue 11

Other

Open Access

Microbe Profile: Wolbachia: a sex selector, a viral protector and a target to treat filarial nematodes

This article is part of the Microbe Profiles collection.

Mark J. Taylor¹, Seth R. Bordenstein^2,3,4,5 and Barton Slatko⁶
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Affiliations: ¹ 1Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK ² 2Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA ³ 3Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA ⁴ 4Vanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University, Nashville, TN, USA ⁵ 5Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA ⁶ 6New England Biolabs, Inc., 240 County Road, Ipswich, MA 01938, USA
*Correspondence: Mark J. Taylor [email protected]
Published: 12 October 2018 https://doi.org/10.1099/mic.0.000724

Abstract

Wolbachia is the most widespread genus of endosymbiotic bacteria in the animal world, infecting a diverse range of arthropods and nematodes. A broad spectrum of associations from parasitism to mutualism occur, with a tendency to drive reproductive manipulation or influence host fecundity to spread infection through host populations. These varied effects of Wolbachia are exploited for public health benefits. Notably, the protection of insect hosts from viruses is being tested as a potential control strategy for human arboviruses, and the mutualistic relationship with filarial nematodes makes Wolbachia a target for antibiotic therapy of human and veterinary nematode diseases.

Received: 31/05/2018
Accepted: 03/09/2018
Published Online: 12/10/2018

Keyword(s): Wolbachia

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Volume 164, Issue 11

Other

Open Access

Microbe Profile: Wolbachia: a sex selector, a viral protector and a target to treat filarial nematodes

This article is part of the Microbe Profiles collection.

Abstract

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